Publications
Avidin combats Alzheimer’s disease with powerful clinical candidate Q134R
by Sompol, J. L. Gollihue, S. D. Kraner, I. A. Artiushin, R. A. Cloyd, E. A. Chishti, S. A. Koren, G. K. Nation, J. F.
Synthesis and In Vitro Cytotoxicity and Antibacterial Activity of Novel 1,2,3-Triazol-5-yl-Phosphonates
by Anna Tripolszky 1 , Emese Tóth 1, Pál Tamás Szabó 2, László Hackler Jr. 3, Beáta Kari 3, László G. Puskás 3,* and Erika
Single Cell Mass Cytometry Revealed the Immunomodulatory Effect of Cisplatin Via Downregulation of Splenic CD44+, IL-17A+ MDSCs and Promotion of Circulating IFN-γ+ Myeloid Cells in the 4T1 Metastatic Breast Cancer Model
by József Á. Balog 1,2, László Hackler Jr. 3, Anita K. Kovács 4, Patrícia Neuperger 1,2, Róbert Alföldi 2,3, Lajos I. Nagy 4, László G.
Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent
by László Hackler, Jr. 1, Márió Gyuris 1, Orsolya Huzián 2, Róbert Alföldi 2, Gábor J. Szebeni 1 , Ramóna Madácsi 1, Levente Knapp 2,
The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis
Molecules. 2019 Apr 19;24(8). pii: E1546.
Imidazo[1,2-b]pyrazole-7-carboxamides Induce Apoptosis in Human Leukemia Cells at Nanomolar Concentrations
Molecules. 2018 Nov 1;23(11). pii: E2845.
Synthesis and Cytoprotective Characterization of 8-hydroxyquinoline Betti Products
Molecules. 2018 Aug 2;23(8). pii: E1934.
Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides Arch
Pharm (Weinheim). 2018 Jul;351(7):e1800062. Epub 2018 Jun 10.
One-pot synthesis of diverse N,N’-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines
Org Biomol Chem. 2018 Mar 8. PMID: 29517090
Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2 H-Azirines via Joullié-Ugi Three-Component Reaction
J. Org. Chem., 2018, 83 (7), pp 3570–3581
Intelligent image-based in situ single-cell isolation
Nat Commun. 2018 Jan 15;9(1):226. PMID: 29335532
Decoding DNA labels by melting curve analysis using real-time PCR
Biotechniques. 2017 Dec 1;63(6):261-266. PMID: 29235972
Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells
Int J Mol Sci. 2017 Oct; 18(10): 2105.
Mannich Curcuminoids as Potent Anticancer Agents
Arch Pharm (Weinheim). 2017 Jul;350(7).
A novel pleiotropic effect of aspirin: Beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells
Brain Res Bull. 2017 Jun;132:61-74.
The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.
Sci Rep. 2017 Feb 16;7:42014.
Real architecture for 3D Tissue (RAFT™) culture system improves viability and maintains insulin and glucagon production of mouse pancreatic islet cells
Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters
Mediators Inflamm. 2017;2017:9294018.
Human neuronal changes in brain edema and increased intracranial pressure.
Acta Neuropathol Commun. 2016 Aug 4;4(1):78.
Novel Anti-CRR9/CLPTM1L Antibodies with Antitumorigenic Activity Inhibit Cell Surface Accumulation, PI3K Interaction, and Survival Signaling
Mol Cancer Ther. 2016 May;15(5):985-97. Epub 2016 Mar 3.
The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.
PLoS One. 2016 Mar 4;11(3):e0149832. eCollection 2016.
Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells
Neuroscience. 2016 Feb 9;314:47-63. Epub 2015 Nov 26.
The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma
Oncotarget. 2015 Oct 6;6(30):29111-28.
AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects
Autophagy. 2016;12(2):273-86.
The potential of three-dimensional tumor models and cell culturing in cancer research and diagnostics
Magy Onkol. 2015 Dec;59(4):303-9. Epub 2015 Jul 15.
Novel real-time cell analysis platform for the dynamic monitoring of ionizing radiation effects on human tumor cell lines and primary fibroblasts
Mol Med Rep. 2015 Sep;12(3):4610-1619. Epub 2015 Jun 26.
Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells
Biochim Biophys Acta. 2015 Sep;1851(9):1271-82. Epub 2015 Jun 16.
Curcumin and its analogue induce apoptosis in leukemia cells and have additive effects with bortezomib in cellular and xenograft models
Biomed Res Int. 2015;2015:968981. Epub 2015 May 17.
Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity
J Exp Med. 2015 Jan 12;212(1):15-22. Epub 2014 Dec 15.
Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury
Arch Med Res. 2014 Nov;45(8):753-64. Epub 2014 Nov 13.
Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach
Beilstein J Org Chem. 2014 Oct 8;10:2338-44. eCollection 2014.
Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration
J Cell Sci. 2014 Aug 1;127(Pt 15):3240-56. Epub 2014 Jun 3.
Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells
PLoS One. 2014 Jul 17;9(7):e100152. eCollection 2014.
Anti-inflammatory effect of recreational exercise in TNBS-induced colitis in rats: role of NOS/HO/MPO system
Oxid Med Cell Longev. 2014;2014:925981. Epub 2014 Feb 6.
GABAergic neurogliaform cells represent local sources of insulin in the cerebral cortex
J Neurosci. 2014 Jan 22;34(4):1133-7.
Lipid droplet binding thalidomide analogs activate endoplasmic reticulum stress and suppress hepatocellular carcinoma in a chemically induced transgenic mouse model
Lipids Health Dis. 2013 Nov 22;12:175.
Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents
Med Chem. 2013 Nov;9(7):911-9.
Synthesis of novel pyrazole-based heterocycles via a copper(II)-catalysed domino annulation
Org Biomol Chem. 2013 Oct 7;11(37):6320-7.
Digital PCR to determine the number of transcripts from single neurons after patch-clamp recording
Biotechniques. 2013 Jun;54(6):327-36.
Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells
Lipids Health Dis. 2010 Jun 2;9:56.
A cell-microelectronic sensing technique for the screening of cytoprotective compounds
Int J Mol Med. 2010 Apr;25(4):525-30.