One-pot synthesis of diverse N,N’-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

Org Biomol Chem. 2018 Mar 8.

PMID: 29517090 DOI: 10.1039/c7ob03109b


Abstract

A sequential one-pot approach towards N,N’-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.