One-pot synthesis of diverse N,N’-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

A sequential one-pot approach towards N,N’-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.