Medicinal chemistry

Avidin’s Chemical Department develops novel chemical synthetic routes to prepare NCEs for the improvement of Avidin’s small molecule collection. For in-house and fee for service projects Avidin performs lead optimization , and focused library synthesis.

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The laboratory is equipped with the following instruments:

ANALYTICAL CHEMISTRY

PURIFICATION: COMBIFLASH Rf SYSTEM Rapid and excellent purification of reaction mixture Purification of gramm scales crude products
OPLC 50 Over Pressure Layer Chromatography is a powerful separation technique employing a planar chromatography bed. Purification of small amount (up to 100 mg) of compounds
ANALYSIS: SHIMADZU® LC-10ATMonitoring the reactions Checking the purity of synthesized and previously purified (by column chromatography and/or recrystallisation) target compounds
FINNIGAN® LCQ MS Electrospray (ESI) and APCI ionization Full mass spectrum of analytes (Full-scan MS mode) Molecular weight information on pure compounds
ORGANIC/MEDICINAL CHEMISTRY RESEARCH:
-Microwave assisted tandem and domino cyclisations (small molecules; N-containing heterobi- and tricycles) -Green Chemistry in water (multicomponent reactions, Ugi- (U-4C), modified Passerini- and Betti- reactions) These single-mode microwave synthesis systems are used for research in the fields of drug discovery and small molecule synthesis
RESEARCH AND DEVELOPMENT QUEST 205 and QUEST 210 Controlled time and reaction temperature Run up to 20 liquid or solid phase organic chemistry reactions in parallel

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