Avidin’s Chemical Department develops novel chemical synthetic routes to prepare NCEs for the improvement of Avidin’s small molecule collection. For in-house and fee for service projects Avidin performs lead optimization , and focused library synthesis.

library_synth

The laboratory is equipped with the following instruments:

ANALYTICAL CHEMISTRY

PURIFICATION:
COMBIFLASH Rf SYSTEM

Rapid and excellent purification of reaction mixture
Purification of gramm scales crude products

OPLC 50

Over Pressure Layer Chromatography is a powerful separation technique employing a planar chromatography bed.
Purification of small amount (up to 100 mg) of compounds

ANALYSIS:
SHIMADZU® LC-10ATMonitoring the reactions
Checking the purity of synthesized and previously purified (by column chromatography and/or recrystallisation) target compounds

FINNIGAN® LCQ MS

Electrospray (ESI) and APCI ionization
Full mass spectrum of analytes (Full-scan MS mode)
Molecular weight information on pure compounds

ORGANIC/MEDICINAL CHEMISTRY
RESEARCH:

-Microwave assisted tandem and domino cyclisations
(small molecules; N-containing heterobi- and tricycles)

-Green Chemistry in water
(multicomponent reactions, Ugi- (U-4C), modified Passerini- and Betti- reactions)

These single-mode microwave synthesis systems are used for research in the fields of drug discovery and small molecule synthesis

RESEARCH AND DEVELOPMENT
QUEST 205 and QUEST 210

Controlled time and reaction temperature
Run up to 20 liquid or solid phase organic chemistry reactions in parallel

For further details and quotation please contact us!