Our most advanced project’s lead optimization results published

Novel 8-hydroxyquinoline pharmacophore scaffold was synthetized by Avidin’s Medicinal Pharmacolgy department which has been shown to possess a range of activities as metal chelation, enzyme inhibition, cytotoxicity and cytoprotection. Based on our previous findings we set out to optimize the scaffold for cytoprotective activity for its potential application in central nervous system …

Avidin organized the fifth TAT-CF general assembly held in Budapest.

The famous Géllert Hotel was the venue selected for meeting. Thursday 14th was dedicated to a workshop session where all the partners presented the most recent progress in their respective work packages. Exciting results from TAT-CF selected hits raised the expectations toward a successful outcome of the project. A total …

Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2H-Azirines via Joullié–Ugi Three-Component Reaction

Lewis Acid-Catalyzed Diastereoselective Synthesis of Multisubstituted N-Acylaziridine-2-carboxamides from 2H-Azirines via Joullié–Ugi Three-Component Reaction (doi: 10.1021/acs.joc.7b03189) 3-9-2018 Avidin’s Medicinal Chemistry Department developed and established an innovative protocol for a ZnCl2-catalyzed diastereoselective Joullié-Ugi three-component reaction from 2 H-azirines, isocyanides, and carboxylic acids. The protocol allows the preparation of highly and diversely functionalized N-acylaziridine-2-carboxamide …

Our single cell protection buffer, the SingleCellProtectTM

Our single cell protection buffer, the SingleCellProtectTM  was used in a recently published Nature Communication paper (doi:10.1038/s41467-017-02628-4) 3-4-2018 Previously we showed that single cells collected for genomic analysis without our protection buffer resulted in more variations and less RNA both in RNASeq and quantitative real-time PCR methods. Our specially formulated …