High-throughput analysis using LightCycler® 1536 Real-Time PCR System

The LightCycler® 1536 System is a novel platform, capable of performing qPCR-based DNA/RNA analysis in an array-like format at high-speed, in a proprietary multiwell plate in 1536-format. Scaling qPCR to a higher throughput, with concurrent miniaturization of individual reactions, provides a new generation of an enabling nucleic acid analysis system, combining the strengths of qPCR with the parallelism and throughput …

Cell Biology And Screening

Avidin has recently set up a label-free screening laboratory, where three cutting edge technologies were established, the Enspire plate reader from Perkin Elmer, the xCelligence system from Roche/Acea and the holographic microscopy from Phiab. Besides using these technologies for in-house screening programmes, Avidin provides the following SERVICES: Real-time measurements of the cytotoxic effects of small molecules/mixtures/extracts on primary cells or …

Lead Optimization

Hit and lead discovery for any targets Provide the name of the target, and we give you patentable NCEs and core structures within 2-3 months! Besides using the latest label-free technologies for in-house screening programmes, Avidin provides the following SERVICES: Real-time measurements of the cytotoxic effects of small molecules/mixtures/extracts on primary cells or cancer cells in a medium high throughput …

Library Preparation

For in-house and fee for service projects Avidin prepares chemical libraries for hit discovery and lead optimization.

Mycoplasma Detection and Treatment

Mycoplasma Detection and Treatment In cell culturing mycoplasma contamination is a major problem regarding both research and industrial production. Unlike fungal or bacterial infections, mycoplasmal contaminations cannot be detected by visual inspection, but can lead to unreliable experimental results and potential unsafe biological products.    Mycoplasmal contamination can be quantified and treated by Avidin’s products: 1. MycoQuantTM kit (Cat# MQ-050, MQ-100, MQ-250) is an …

OpenArray® DLP Real-Time qPCR System

The OpenArray Real-Time qPCR platform now enables the use of the proven, market-leading TaqMan® chemistry in a faster, more flexible format. This unique parallel array format, enables unprecedented gene coverage and sample throughput. OpenArray DLP allows just one user to easily obtain 30,000 data points in just one day, allowing many projects to be completed in just days instead of …

Custom pathways

OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human, rat or mouse genes. New panels are continually under development. Available human panels: ADME Apoptosis Cancer Cardiovascular Disease Drug Targets GPCRs Housekeeping genes Inflammation Kinome Signal Transduction Transcription Factors …

Medicinal chemistry

Avidin’s Chemical Department develops novel chemical synthetic routes to prepare NCEs for the improvement of Avidin’s small molecule collection. For in-house and fee for service projects Avidin performs lead optimization , and focused library synthesis. The laboratory is equipped with the following instruments: ANALYTICAL CHEMISTRY PURIFICATION: COMBIFLASH Rf SYSTEM Rapid and excellent purification of reaction mixture Purification of gramm scales …

Toxicity

Avidin provides a non-GLP acute and sub-chronic toxicology service on mice or rats. Traditional, as well as more complex toxicogenomical approach is also available. A) Traditional pathological examination, LD50 determination in general or focused on organ-specific manifestations. B) Toxicogenomics analysis of tissue- and organ-specific gene markers on nanocapillary HTS QRT-PCR panels. Expression of 56 genes are followed after in vivo …