Curcumin analogs

New Analogues Avidin has synthesized more than 70 curcumin analogs with novel scaffold. Analogues have been optimized for better cytotoxic profiles, and efficacy in vivo. The synthesis of the lead molecule, C-150 is straightforward and can be easily upscaled. Preclinical Results C-150 showed impressive effectiveness against human acute myeloid leukemia (AML) injected intravenously into SCID mice. The LD50 for the …

Inflammation

Prostiazol Researchers at Avidin have synthesized analogues of a novel prostaglandin with strong anti-inflammatory effects. Avidin is looking for partners for out-licensing/co-development/repurposing to other inflammatory diseases. Chemistry Prostiazol is a semi-synthetic derivative of a naturally occurring prostaglandin derivate. The synthesis of the prostaglandin intermediate was quite long (22 chemical steps) but has been optimized (at present only 13 steps are …

alstriol

Alstriol

Alstriol is a potent, orally active, rapidly-acting antidepressant with exceptional effects on hippocampal neurons with no toxic effects. Depression is the most frequently diagnosed psychiatric disorder. The problem of treatment resistance is augmented by another issue in the clinical management of major depressive disorder, which is the long delay in the antidepressant response. All antidepressant drugs currently approved for the …

kinolol

Kinolol

Researchers at Avidin have synthesized analogues of novel quinoline analogues may have potential applications in anxiety disorders and Alzheimer’s disease (AD). The IP held by Avidin on the novel structure and its application is valuable, offering the possibility of widening the application of the drug candidate. Kinolol compounds exert neuroprotective action in vitro, they orally active as anti-anxiety drugs in …

Chemical Labrary

Chemical Library

Avidin’s Screening Compound Collection has proved to be a valuable source for in-house and outsourced drug screening projects. The library covers distinct chemical space with less than 10% overlap with other HTS compound libraries. The high complexicity was our main focus, which was achieved by combining different small rare chemical libraries with our own chemical entities. Avidin’s Screening Compound Collection …

Glinolid

Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. Under hypoxic conditions or when free fatty acids overload can occur (exogenously from the serum or due to intracellular alterations e.g. when beta-oxidation is blocked) the number of LDs are increasing. It was shown that LD accumulation occurs in vivo at prenecrotic cancer tissues and border zones of experimental myocardial infarcts, therefore LDs can be in vivo markers of cancer and ischemic insults.

Avinomid

drug_discoveryResearchers at Avidin have synthesized analogues of novel thalidomide-related Immune Modulatory Drugs (IMIDs) which may have benefits over the current treatments for solid tumors. The IP held by Avidin on the novel IMIDs, the trifluorinated-alkylamino-imids is valuable, offering the possibility of widening the application of the currently used thalidomide or RevlimidTM (Celgene Inc.).